Have an antioxidant effect, takes part in the biosynthesis of heme and protein, cell proliferation, tissue respiration and other important metabolic processes of the tissue, prevents hemolysis, elevated reduces capillary fragility and permeability. It is necessary for the development and functioning of connective tissue, smooth and skeletal muscle, as well as to strengthen the walls of blood vessels. Participates in the metabolism of nucleic acids and prostaglandins, cellular respiratory cycle in the synthesis of arachidonic acid. It is a natural antioxidant that inhibits lipid peroxidation by free radicals. Activates phagocytosis and is used to maintain the normal resistance of erythrocytes. In large doses, it prevents platelet aggregation. It has a pronounced positive effect on the human reproductive system, slows the progression of atherosclerotic vascular changes.
When ingestion absorbed 20% -40% (requires the presence of bile and the normal functioning of the pancreas). At higher doses reduced the degree of absorption.The optimum concentration in blood of 10-15 mg / l. Excretion mainly in the faeces.
Less than 1% is excreted in the urine as glucuronides and other metabolites.
- prevention and treatment of vitamin E hypovitaminosis;
- in complex therapy for hormonal treatment of menstrual disorders, degenerative and proliferative changes in the joints and ligaments of the spine system, muscular dystrophy, amyotrophic lateral sclerosis with;
- state of convalescence after an illness;
- inadequate and unbalanced nutrition
- increased physical activity.Contraindications
: Hypersensitivity to the drug, acute myocardial infarction, child.
Be wary – in patients with severe cardiosclerosis, myocardial infarction, with an increased risk of thromboembolism; hypoprothrombinemia caused by deficiency of vitamin K, may deteriorate when using vitamin E at a dose of 400 ME.
Use during pregnancy and breastfeeding.
During pregnancy and breast-feeding taking this medication only on doctor’s advice.
Dosage and administration
andriol side effects 100 mg:. Adult 2-4 andriol side effects per day
andriol side effects 200 mg:. Adult 1-2 andriol side effects per day
andriol side effects 400 mg:. Adults: 1 capsule per day
in the menstrual cycle (as a supplement to hormone therapy) 300-400 mg every other day series, starting with the 17 day cycle.
Allergic reactions; on the part of the gastrointestinal tract: diarrhea, nausea, gastralgia. Rarely, patients with a predisposition arises kreatinuriya, increased creatine kinase activity, increased cholesterol level in the blood serum, thrombophlebitis, pulmonary embolism, thrombosis.
High doses of vitamin E (400-800 mg per day for a long time) can cause blurred vision, diarrhea, dizziness, headache, nausea, severe fatigue, syncope, increase of white hair on the areas of alopecia with epidermolysis bubble.
Very high doses ( greater than 800 mg for a long time) may cause bleeding in patients with deficiency of vitamin K; they may interfere with the metabolism of thyroid hormones and increase the risk of thrombophlebitis and thromboembolism in sensitive patients. Treatment: symptomatic, removal of the drug.
Interaction with other drugs
Enhances the effect of corticosteroids, non-steroidal anti-inflammatory drugs, cardiac glycosides. It improves the effectiveness of antiepileptic drugs in patients with epilepsy (in which elevated blood lipid peroxidation products).
Iron increases the daily requirement for vitamin E. Vitamin E enhances the effect of anticoagulants, if doses exceeding 400 ME per day.
Not recommended concomitant use of other vitamin complexes, containing vitamin E, in order to avoid overdoses.
Appointment of vitamin E in high doses can cause a deficiency of vitamin a in the body.
Simultaneous use of vitamin E at a dose of 400 ME in the day with anticoagulants (coumarin derivatives and indandiona) increases the risk of gipotrombinemii and bleeding.
Kolestiramin, colestipol, reduce the absorption of mineral oils.
When epidermolysis bullosa in areas affected by alopecia can begin to grow white hair.
Form release andriol side effects of 100 mg, 200 mg: 30 andriol side effects in a bottle of dark glass. andriol side effects 400 mg: . 20 or 30 andriol side effects in dark glass bottles Each bottle with instruction on the medical application is placed in a cardboard box.