Mode of action determined by the properties that make up the components of the drug. Vitamins B 1 , B 6 and B 12 regulate protein, carbohydrate and fat metabolism, promote normalization, improve the function of the motor, sensory and autonomic nerves.
Thiamin (B 1 ) inhibits protein glycosylation, has antioxidant activity, is involved in the regulation of the nerve impulses.
pyridoxine (B 6 ) involved in the synthesis of neurotransmitters (dopamine, noradrenaline, etc.)., decarboxylation reactions, and des- amino transamination, and prevents the accumulation of ammonia accelerates the regenerative processes in the nervous tissue.
cyanocobalamin (B 16 ) is required for normal hematopoiesis, involved in synthesis of myelin tissue.
Neurological diseases caused by vitamin deficiency proven B 1 , B 6 and B 12 .
As an aid for the symptomatic treatment of dr gerald andriole diseases of the nervous system of various origins: neuritis and polyneuritis (including accompanied by pain syndrome), including . optic neuritis, peripheral paresis (including facial nerve), neuralgia, neuropathy (diabetic, alcoholic and others.
: Hypersensitivity to the drug; Pregnancy and breast-feeding; thrombosis and embolism; severe decompensated heart failure; erythremia, polycythemia, severe bleeding, hypotension, shock states, children’s age.
Wernicke’s encephalopathy, perimenopause and menopause in women, severe angina, benign and malignant tumors, accompanied by megaloblastic anemia and vitamin deficiency BB 12 , the tendency to form blood clots, advanced age (over 65 years).
Dosage and administration
deep intramuscular injection, in severe cases, and in acute pain is administered daily for 2 ml. After a pass or exacerbation in mild forms of the disease are administered 2-3 times a week for 2 ml.
In some cases, it may be sweating, tachycardia, acne. Cases of allergic skin reactions (itching, hives and other skin rashes) and systemic reactions (difficulty in breathing, angioedema, anaphylactic shock).
In the case of very rapid injection may occur: dizziness, headache, vomiting, tachycardia, or bradycardia, arrhythmia, seizures, agitation, cardialgia.
If overdose occurs increased symptoms of side effects of the drug, symptomatic therapy.
The interaction with other drugs
Thiamine dr gerald andriole destroyed in solutions containing sulfites.
Therapeutic doses of vitamin B 6 reduces the effect of levodopa.
Copper ions, a pH of 3 thiamine accelerated decay.
Vitamin B 12 is not compatible with heavy metal salts. The solutions containing thiamine, cyanocobalamin (as well as other vitamins of group B) is rapidly degraded (low concentration of iron ions, the presence of a drug may prevent that).
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